### Diego Ulisse Pizzagalli: Image driven systems immunology via semi-supervised machine learning and in-vivo microscopy

This talk describes the combination of machine learning with
microscopy techniques for investigating the mechanisms of the immune
system. After giving an overview about the applications of machine
learning to in-vivo imaging, the capabilities of a graph-based,
semi-supervised clustering algorithm will be presented.
More in details, the immune system involves a complex network of
cellular interactions. This network can be described as a system whose
output can be either protective (i.e. from pathogens and tumors) or
pathogenic (i.e. leading to autoimmune diseases). In-vivo video
microscopy (IVM) is a recently developed method to investigate the
behavior of the immune system in living animals. IVM acquires 4D
videos capturing the migration of cells which correlates to their
spatiotemporal interaction patterns. However, automatic classical
automatic analysis methods for this type of data require cell
segmentation and tracking which are challenging due to the high
plasticity, lack of textures and frequent contacts between cells. To
this end, we present a semi-supervised clustering algorithm for
segmentation and tracking by grouping voxels according with a
trainable grouping criterion. Moreover, we present novel analysis
methods that do not require segmentation nor tracking.
*IDSIA, Galleria 1*

### Mauro Manconi: Infraslow Oscillations and Periodic Leg Movements during Sleep

Oscillations are a fundamental property of life and oscillatory activity is observed throughout the central nervous system at all levels of organization. They are observed across vastly different time scales ranging from year-long cycles to milliseconds. Oscillations interact across different time scales in a complex manner with one of the emerging principles being that lower level (faster) oscillations are embedded in higher level (slower) oscillations. Sleep is a prototype for such a multilevel oscillation. On the one hand, sleep is part of the slower oscillation of the circadian cycle, which interacts with the homeostatic oscillator to regulate the timing and the intra-sleep dynamics. Sleep itself is made up of ultradian cycles, that is, the 90 to 120 minute cycle between non-rapid-eye-movement (NREM) sleep and REM sleep. NREM sleep again consists of several sleep stages, currently labeled N1 to N3, which denote the succession from lighter to deeper, slow wave sleep. The specific sleep stage is characterized by the predominance of brain activity oscillations that include several EEG frequency bands. Bridging the gap between the EEG frequency bands and the ultradian cycle, recent research has begun to characterize a further oscillation of brain activity that is even slower than the slow waves and represents multi-second oscillations with periodicities between 10 to 100 s. These oscillations are called infra-slow oscillations (ISO) and include a synchronous oscillations of motor (periodic legs movements), autonomic and cortical activity during sleep. The physiological as well the pathological meaning of the motor component of ISO has become an hot topic in sleep research.*Manno, Galleria 1, 2nd floor, room G1-201*

### Ganna Marchenko: Clustering non-stationary financial time series data

Non-stationarity in data can arise due to the changes in various unobserved influencing factors. One way to account for non-stationarity is to employ models with time-varying parameters. Such models can be parametric or non-parametric depending on underlying assumptions they impose. The presented non-stationary approach identifies the optimal number of hidden regimes in data and the (a priori unknown) regime-switching dynamic without employing restrictive parametric assumption about the data-generating process. Within the regime, data is modelled using Maximum Entropy density, where the optimal number of density parameters is inferred via Lasso regularization technique. The resulting non-parametric methodology provides simultaneously the simplest and the least biased description of the data.*IDSIA meeting room @10:00*

### E Merelli and M Piangerelli: Topology driven methods for complex systems modeling, an alternative approach to machine learning. Theory and some examples.

Many complex systems are characterized by multi-level properties that make the study of their dynamics and of their emerging phenomena a daunting task. The huge amount of data available in modern sciences can be expected to support great progress in these studies, even though the nature of the data varies. Given that, it is crucial to extract as much as possible features from data, including qualitative (topological) ones. The goal of TOPDRIM project has been to provide methods driven by the topology of data for describing the dynamics of multi-level complex systems. To this end, the project has developed new mathematical and computational formalisms accounting for topological effects. To pursue these objectives, the project brought together scientists from many diverse fields including as topology and geometry, statistical physics and information theory, computer science and biology. The proposed methods, obtained through concerted efforts, covered different aspects of the science of complexity ranging from foundations, to simulations through modelling and analysis, and constituted the building blocks for a new generalized theory of complexity.
This seminar introduces the fundamentals behind the topological data analysis and through some applications developed both in the biomedical and financial field, presents the TOPDRIM methodology for going beyond the concept of networks by considering simplicial
complexes instead.*Manno, Galleria 1, 2nd floor, room G1-201 @12:00*

### Fabrizio Grandoni: How to Pack your Rectangles?

Suppose that I give you a square and a collection of rectangles of
different shapes. How many rectangles can you pack into the square (so
that they do not overlap)? This and related problems are NP-hard. In this talk I will present approximation algorithms to efficiently pack a number of rectangles close to the optimum. The talk is meant to be accessible to non-experts.
*Manno, Galleria 1, 2nd floor, room G1-204 @12h00*

### Monaldo Mastrollilli: What is a Groebner Basis?

A Groebner basis is a set of multivariate polynomials that has desirable algorithmic properties.
Every set of polynomials can be transformed into a Groebner basis.
This process generalizes three familiar techniques (and more):
1) Gaussian elimination for solving linear systems of equations,
2) the Euclidean algorithm for computing the greatest common divisor of two univariate polynomials,
3) and the Simplex Algorithm for linear programming.
In this talk I'll give a gentle introduction to Groebner bases.
No prior knowledge is required.
*Manno, Galleria 1, 2nd floor, room G1-201 @12:00*

### Jobst Landgrebe and Barry Smith: Ontology-Driven Automotive Repair Claims Management

We are experiencing once again a period of enthusiasm in the AI research field, fired above all by the successes of the technology of deep neural networks or deep machine learning. In this talk we draw attention to what we take to be serious problems underlying current views of artificial intelligence encouraged by these successes, especially in the domain of language processing. We then show an alternative approach to language-centric AI, and illustrate this approach in relation to a specific example in the field of claims management. *Manno, Galleria 1, 2nd floor, room G1-201 @12:00*